Schedule for San Francisco 49ers for 2008 season
| Week | Opponent | Result | ||
| 1 | ARI | L 13-23 | play by play | graph |
| 2 | @SEA | W 33-30 | play by play | graph |
| 3 | DET | W 31-13 | play by play | graph |
| 4 | @NO | L 17-31 | play by play | graph |
| 5 | NE | L 21-30 | play by play | graph |
| 6 | PHI | L 26-40 | play by play | graph |
| 7 | @NYG | L 17-29 | play by play | graph |
| 8 | SEA | L 13-34 | play by play | graph |
| 10 | @ARI | L 24-29 | play by play | graph |
| 11 | STL | W 35-16 | play by play | graph |
| 12 | @DAL | L 22-35 | play by play | graph |
| 13 | @BUF | W 10-3 | play by play | graph |
| 14 | NYJ | W 24-14 | play by play | graph |
| 15 | @MIA | L 9-14 | play by play | graph |
| 16 | @STL | W 17-16 | play by play | graph |
| 17 | WAS | W 27-24 | play by play | graph |