Schedule for Indianapolis Colts for 2008 season
| Week | Opponent | Result | ||
| 1 | CHI | L 13-29 | play by play | graph |
| 2 | @MIN | W 18-15 | play by play | graph |
| 3 | JAC | L 21-23 | play by play | graph |
| 5 | @HOU | W 31-27 | play by play | graph |
| 6 | BLT | W 31-3 | play by play | graph |
| 7 | @GB | L 14-34 | play by play | graph |
| 8 | @TEN | L 21-31 | play by play | graph |
| 9 | NE | W 18-15 | play by play | graph |
| 10 | @PIT | W 24-20 | play by play | graph |
| 11 | HOU | W 33-27 | play by play | graph |
| 12 | @SD | W 23-20 | play by play | graph |
| 13 | @CLE | W 10-6 | play by play | graph |
| 14 | CIN | W 35-3 | play by play | graph |
| 15 | DET | W 31-21 | play by play | graph |
| 16 | @JAC | W 31-24 | play by play | graph |
| 17 | TEN | W 23-0 | play by play | graph |