Schedule for Buffalo Bills for 2008 season
| Week | Opponent | Result | ||
| 1 | SEA | W 34-10 | play by play | graph |
| 2 | @JAC | W 20-16 | play by play | graph |
| 3 | OAK | W 24-23 | play by play | graph |
| 4 | @STL | W 31-14 | play by play | graph |
| 5 | @ARI | L 17-41 | play by play | graph |
| 7 | SD | W 23-14 | play by play | graph |
| 8 | @MIA | L 16-25 | play by play | graph |
| 9 | NYJ | L 17-26 | play by play | graph |
| 10 | @NE | L 10-20 | play by play | graph |
| 11 | CLE | L 27-29 | play by play | graph |
| 12 | @KC | W 54-31 | play by play | graph |
| 13 | SF | L 3-10 | play by play | graph |
| 14 | MIA | L 3-16 | play by play | graph |
| 15 | @NYJ | L 27-31 | play by play | graph |
| 16 | @DEN | W 30-23 | play by play | graph |
| 17 | NE | L 0-13 | play by play | graph |