Schedule for San Francisco 49ers for 2006 season
| Week | Opponent | Result | ||
| 1 | @ARI | L 27-34 | play by play | graph |
| 2 | STL | W 20-13 | play by play | graph |
| 3 | PHI | L 24-38 | play by play | graph |
| 4 | @KC | L 0-41 | play by play | graph |
| 5 | OAK | W 34-20 | play by play | graph |
| 6 | SD | L 19-48 | play by play | graph |
| 8 | @CHI | L 10-41 | play by play | graph |
| 9 | MIN | W 9-3 | play by play | graph |
| 10 | @DET | W 19-13 | play by play | graph |
| 11 | SEA | W 20-14 | play by play | graph |
| 12 | @STL | L 17-20 | play by play | graph |
| 13 | @NO | L 10-34 | play by play | graph |
| 14 | GB | L 19-30 | play by play | graph |
| 15 | @SEA | W 24-14 | play by play | graph |
| 16 | ARI | L 20-26 | play by play | graph |
| 17 | @DEN | W 26-23 | play by play | graph |