Schedule for Indianapolis Colts for 2006 season
| Week | Opponent | Result | ||
| 1 | @NYG | W 26-21 | play by play | graph |
| 2 | HOU | W 43-24 | play by play | graph |
| 3 | JAC | W 21-14 | play by play | graph |
| 4 | @NYJ | W 31-28 | play by play | graph |
| 5 | TEN | W 14-13 | play by play | graph |
| 7 | WAS | W 36-22 | play by play | graph |
| 8 | @DEN | W 34-31 | play by play | graph |
| 9 | @NE | W 27-20 | play by play | graph |
| 10 | BUF | W 17-16 | play by play | graph |
| 11 | @DAL | L 14-21 | play by play | graph |
| 12 | PHI | W 45-21 | play by play | graph |
| 13 | @TEN | L 17-20 | play by play | graph |
| 14 | @JAC | L 17-44 | play by play | graph |
| 15 | CIN | W 34-16 | play by play | graph |
| 16 | @HOU | L 24-27 | play by play | graph |
| 17 | MIA | W 27-22 | play by play | graph |
| (post) | KC | W 23-8 | play by play | graph |
| (post) | @BAL | W 15-6 | play by play | graph |
| (post) | NE | W 38-34 | play by play | graph |
| (post) | @CHI | W 29-17 | play by play | graph |