Schedule for Detriot Lions for 2006 season
| Week | Opponent | Result | ||
| 1 | SEA | L 6-9 | play by play | graph |
| 2 | @CHI | L 7-34 | play by play | graph |
| 3 | GB | L 24-31 | play by play | graph |
| 4 | @STL | L 34-41 | play by play | graph |
| 5 | @MIN | L 17-26 | play by play | graph |
| 6 | BUF | W 20-17 | play by play | graph |
| 7 | @NYJ | L 24-31 | play by play | graph |
| 9 | ATL | W 30-14 | play by play | graph |
| 10 | SF | L 13-19 | play by play | graph |
| 11 | @ARI | L 10-17 | play by play | graph |
| 12 | MIA | L 10-27 | play by play | graph |
| 13 | @NE | L 21-28 | play by play | graph |
| 14 | MIN | L 20-30 | play by play | graph |
| 15 | @GB | L 9-17 | play by play | graph |
| 16 | CHI | L 21-26 | play by play | graph |
| 17 | @DAL | W 39-31 | play by play | graph |