Schedule for Buffalo Bills for 2006 season
| Week | Opponent | Result | ||
| 1 | @NE | L 17-19 | play by play | graph |
| 2 | @MIA | W 16-6 | play by play | graph |
| 3 | NYJ | L 20-28 | play by play | graph |
| 4 | MIN | W 17-12 | play by play | graph |
| 5 | @CHI | L 7-40 | play by play | graph |
| 6 | @DET | L 17-20 | play by play | graph |
| 7 | NE | L 6-28 | play by play | graph |
| 9 | GB | W 24-10 | play by play | graph |
| 10 | @IND | L 16-17 | play by play | graph |
| 11 | @HOU | W 24-21 | play by play | graph |
| 12 | JAC | W 27-24 | play by play | graph |
| 13 | SD | L 21-24 | play by play | graph |
| 14 | @NYJ | W 31-13 | play by play | graph |
| 15 | MIA | W 21-0 | play by play | graph |
| 16 | TEN | L 29-30 | play by play | graph |
| 17 | @BAL | L 7-19 | play by play | graph |