Schedule for Penn State Nittany Lions for 2006 season
| Week | Opponent | Result | ||
| 1 | Akron | W 34-16 | play by play | graph |
| 2 | @ND | L 17-41 | play by play | graph |
| 4 | @OhioSt | L 6-28 | play by play | graph |
| 5 | NW | W 33-7 | play by play | graph |
| 6 | @Minn | W 28-27 | play by play | graph |
| 7 | Mich | L 10-17 | play by play | graph |
| 8 | Ill | W 26-12 | play by play | graph |
| 9 | @Purdue | W 12-0 | play by play | graph |
| 10 | @Wisc | L 3-13 | play by play | graph |
| 11 | Temple | W 47-0 | play by play | graph |
| 12 | MSU | W 17-13 | play by play | graph |
| bowl | Tenn | W 20-10 | play by play | graph |