Schedule for Louisville Cardinals for 2006 season
| Week | Opponent | Result | ||
| 1 | Kty | W 59-28 | play by play | graph |
| 2 | @Temple | W 62-0 | play by play | graph |
| 3 | Mia-Fl | W 31-7 | play by play | graph |
| 4 | @KanSt | W 24-6 | play by play | graph |
| 6 | @MiddTn | W 44-17 | play by play | graph |
| 7 | Cin | W 23-17 | play by play | graph |
| 8 | @Syr | W 28-13 | play by play | graph |
| 10 | WVU | W 44-34 | play by play | graph |
| 11 | @Rut | L 25-28 | play by play | graph |
| 12 | SoFla | W 31-8 | play by play | graph |
| 13 | @Pitt | W 48-24 | play by play | graph |
| 14 | UConn | W 48-17 | play by play | graph |
| bowl | @Wake | W 24-13 | play by play | graph |